Ethyl 6-ethyl-1,6-dihydropyrrolo[3,2-c]carbazole-2-carboxylate → Ethyl 6-ethyl-1,6-dihydro-1-methylpyrrolo[3,2-c]carbazole-2-carboxylate

HRID 359237Notes

Reaction equation

[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]3[CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[NH:18][C:11]=3[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]1=2)[CH3:2].[CH2:24](Cl)Cl.CCCCCC>>[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]3[CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]([CH3:24])[C:11]=3[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]1=2)[CH3:2]

Participants

Reactant 2

HCID 15170279Ethyl 6-ethyl-1,6-dihydropyrrolo[3,2-c]carbazole-2-carboxylate

HCID 21226440Methylenechloride Hexane

Product 1

HCID 15170280Ethyl 6-ethyl-1,6-dihydro-1-methylpyrrolo[3,2-c]carbazole-2-carboxylateYield 90.5%

Procedure

Using the procedure outlined in Example 34A, ethyl 6-ethyl-1,6-dihydropyrrolo[3,2-c]carbazole-2-carboxylate (H.G. Pars Pharmaceutical Laboratories, Inc.) gave a 90.5% yield of ethyl 6-ethyl-1,6-dihydro-1-methylpyrrolo[3,2-c]carbazole-2-carboxylate, mp 115.5°-116°, (CH2Cl2 /hexane), (C,H,N).

Sources & evidence

ORD record: ord-288ce8f294084dddb1afd569a5b33a63
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04999369

Reaction notes

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