Hydrochloric Acid → HCID 12842605, compound

Participants

Reaction Steps

2-Benzylamino-2-methyl-1,4-butanediol (67E, 31.08 g, 0.149 mol) was dissolved in 95% EtOH (240 mL) containing concentrated HCl (21 mL, 0.25 mol) and 5% Pd/C (10.0 g) and reduced in a Parr apparatus at 40 psi over 37 h at RT. The catalyst was then removed by filtration and the solvent removed by rotary evaporation (bath at 60°) to give 20.91 g of 2-amino-2-methyl-1,4-butanediol hydrochloride (90.2%) as a clear, thick, colorless oil with acceptable NMR and mass spectra. It was used without further purification. This compound has been reported as its actetate salt (G. Cardillo et al., Chem. Commun. 1380, 1982), but no data was given. Attempts to duplicate the latter procedure were unsuccessful.

Provenance & Evidence