Propylene Glycol → HCID 14880907, compound

HRID 359251Notes

Reaction equation

HRID 359251 reaction equation
[C:1]([C:9]1[CH:10]=[N:11][C:12]([Cl:15])=[CH:13][CH:14]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16](O)[CH:17]([OH:19])[CH3:18].B(F)(F)F.CCOCC.[OH-].[Na+]>C1(C)C=CC=CC=1>[Cl:15][C:12]1[N:11]=[CH:10][C:9]([C:1]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[O:19][CH:17]([CH3:18])[CH2:16][O:8]2)=[CH:14][CH:13]=1

Participants

6

Reactant 4

HCID 1030Propylene GlycolHCID 8000Boron trifluoride etherateHCID 14798Sodium HydroxideHCID 3061713Methanone, (6-chloro-3-pyridinyl)phenyl-

Product 1

HCID 14880907HCID 14880907, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To 25 ml of a solution of 1.5 g of 3-benzoyl-6-chloropyridine and 3.2 g of 1,2-propanediol in toluene, 1.2 g of boron trifluoride etherate was added. The resulting mixture was heated under reflux for six hours while removing the water thus formed therefrom. Then the reaction mixture was cooled, poured into an aqueous solution of sodium hydroxide and extracted with ether. The organic phase was washed with water and dried over anhydrous sodium sulfate. After filtering off the sodium sulfate and distilling off the solvent in vacuo, 2-(6-chloropyridin-3-yl)-4-methyl-2-phenyl-1,3-dioxolane was obtained m.p.: 44°-51° C.

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for six hours
  3. customwhile removing the water
  4. customthus formed
  5. temperatureThen the reaction mixture was cooled
  6. extractionextracted with ether
  7. washThe organic phase was washed with water
  8. dry with materialdried over anhydrous sodium sulfate
  9. filtrationAfter filtering off the sodium sulfate
  10. distillationdistilling off the solvent in vacuo

Sources & evidence

ORD record
ord-54978bc34de84cb6b5eb9421afcbbcae
Source dataset
uspto-grants-1991_03
Patent number
US05000778

Reaction notes

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