反应详情

A reaction vessel was charged with 2.8 g of methyl 5-phenyl-2-chloro-4-thiazolecarboxylate and 9.7 g of meta-aminobenzotrifluoride. The reaction mixture was stirred overnight and then heated and stirred at 150° C. for about 6 hours during which time a crystalline solid appeared. The mixture was treated with ethyl ether and water. The ether extract was dried with magnesium sulfate and concentrated. The residue was crystallized from anhydrous ethyl ether to provide a white amorphous powder (m.p. 147°-149° C.) identified in Table I.

1. temperatureheated
2. stirringstirred at 150° C. for about 6 hours during which time a crystalline solid
3. extractionThe ether extract
4. dry with materialwas dried with magnesium sulfate
5. concentrationconcentrated
6. customThe residue was crystallized from anhydrous ethyl ether