Toluene → HCID 20064728, compound

Participants

Reaction Steps

A reaction vessel fitted with a calcium sulfate drying tube was charged with 5 ml of toluene, 0.56 g (2 mmol) of ethyl 2-iodo-4-methyl-5-oxazolecarboxylate and 2 ml (10 mmol) of dibenzylamine. The reaction mixture was stirred overnight at room temperature. The reaction mixture was then heated at reflux for 4 hours, cooled, and then diluted with ethyl ether. The mixture was washed with water, then with 5% hydrochloric acid, and then with water. The ether solution was dried with sodium sulfate and then concentrated under reduced pressure to yield 0.4 g of a yellow glass. This glass was dissolved in hot hexane and then with the vessel cooling in a dry ice bath, a white solid material was deposited. The solid material was filtered off giving 0.35 g of product (m.p.=75°-77° C.) identified in Table I.

Provenance & Evidence