Isobutylurea → Ethyl 2-[(2-methylpropyl)amino]-4-(trifluoromethyl)-5-oxazolecarboxylate

Participants

Reaction Steps

By the procedure of Example 4, 7.0 g (60 mmol) of isobutyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 18 hours. The product was separated and then recrystallized from methylcyclohexane to yield 4.72 g of a yellow powder product (m.p.=43°-44° C.) identified in Table I.

Provenance & Evidence