Cyclohexylurea → HCID 20064772, compound

HRID 359281Notes

Reaction equation

HRID 359281 reaction equation
[CH:1]1([NH:7][C:8]([NH2:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH:12]([C:18]([C:20]([F:23])([F:22])[F:21])=O)[C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[CH:1]1([NH:7][C:8]2[O:9][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:18]([C:20]([F:21])([F:23])[F:22])[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 69684CyclohexylureaHCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

Product 1

HCID 20064772HCID 20064772, compoundYield 38.7%

Procedure

By the procedure of Example 4, 8.52 g (60 mmol) of cyclohexyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 72 hours. The product was separated and then recrystallized several times from methylcyclohexane to yield 5.92 g of a fine white powder product (m.p.=73°-74° C.) identified in Table I.

Workup

  1. customThe product was separated
  2. customrecrystallized several times from methylcyclohexane

Sources & evidence

ORD record
ord-7553301cd39441e59bbb97191240e3f0
Source dataset
uspto-grants-1991_03
Patent number
US05000775

Reaction notes

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