Urea, octyl- → HCID 20064714, compound

HRID 359283Notes

Reaction equation

HRID 359283 reaction equation
[CH2:1]([NH:9][C:10]([NH2:12])=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl[CH:14]([C:20]([C:22]([F:25])([F:24])[F:23])=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[CH2:1]([NH:9][C:10]1[O:11][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:20]([C:22]([F:23])([F:25])[F:24])[N:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 200490Urea, octyl-HCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

Product 1

HCID 20064714HCID 20064714, compoundYield 17.8%

Procedure

By the procedure of Example 4, 5.16 g (30 mmol) of n-octyl urea was reacted with 5.4 g (25 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 18 hours. The product was separated and then recrystallized from petroleum ether to yield 1.5 g of a white powder product (m.p.=36°-37° C.) identified in Table I.

Workup

  1. customThe product was separated
  2. customrecrystallized from petroleum ether

Sources & evidence

ORD record
ord-218145b347304044ade54d99875f9cee
Source dataset
uspto-grants-1991_03
Patent number
US05000775

Reaction notes

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