sec-Butylurea → HCID 20064759, compound

HRID 359285Notes

Reaction equation

HRID 359285 reaction equation
[CH:1]([NH:5][C:6]([NH2:8])=[O:7])([CH2:3][CH3:4])[CH3:2].Cl[CH:10]([C:16]([C:18]([F:21])([F:20])[F:19])=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12]>>[CH3:2][CH:1]([NH:5][C:6]1[O:7][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:16]([C:18]([F:19])([F:21])[F:20])[N:8]=1)[CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 12715sec-ButylureaHCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

Product 1

HCID 20064759HCID 20064759, compoundYield 28.5%

Procedure

By the procedure of Example 4, 6.96 g (60 mmol) of sec-butyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 3 hours. The product was separated and then Kugelrohr distilled to yield 4.0 g of a colorless oil product (b.p.=100° C. @ 0.25 mm Hg) identified in Table I.

Workup

  1. customThe product was separated
  2. distillationKugelrohr distilled

Sources & evidence

ORD record
ord-9470ec00f2cb4ec0949da743a6b5983d
Source dataset
uspto-grants-1991_03
Patent number
US05000775

Reaction notes

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