Butylamine → HCID 20064775, compound

HRID 359289Notes

Reaction equation

HRID 359289 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].Cl[C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[C:10]([C:12]([F:15])([F:14])[F:13])[N:11]=1>C(#N)C>[CH2:1]([NH:5][C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[C:10]([C:12]([F:14])([F:13])[F:15])[N:11]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 91715Flurazole

Product 1

HCID 20064775HCID 20064775, compoundYield 36.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

By the procedure of Example 39, a stirred mixture of 20 ml acetonitrile, 3.65 g (49.8 mmol) of n-butylamine, and 8 g (24.9 mmol) of benzyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506), was heated at reflux for 24 hours. The product was separated and then recrystallized from hexane to yield 3.24 g of a yellow solid product (m.p.=77°-79° C.) identified in Table I.

Workup

  1. customprepared
  2. temperature4,199,506), was heated
  3. temperatureat reflux for 24 hours
  4. customThe product was separated
  5. customrecrystallized from hexane

Sources & evidence

ORD record
ord-002139dbeb3b46189b28db252281427e
Source dataset
uspto-grants-1991_03
Patent number
US05000775

Reaction notes

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