Ethanolamine → 2-[(1,1-dimethylethyl)amino]-N-(2-hydroxyethyl)-4-(trifluoromethyl)-5-oxazolecarboxamide

Participants

Reaction Steps

By the procedure of Example 38, a stirred mixture of 50 ml methylene chloride, 0.70 g (11.46 mmol) of ethanolamine, 1.27 g (12.61 mmol) of triethylamine, and 3.1 g (11.46 mmol) of 2-(tert-butylamino)-4-trifluoromethyl-5-oxazolecarbonyl chloride, was reacted for 64 hours at ambient temperature. The product was separated and then recrystallized to yield 1.16 g of a yellow solid product (m.p.=154°-156° C.) identified in Table 1.

Provenance & Evidence