4-acetyl-5-oxohexanenitrile → HCID 18963356, compound

HRID 359320Notes

Reaction equation

HRID 359320 reaction equation
[C:1]([CH:4]([C:9](=O)[CH3:10])[CH2:5][CH2:6][C:7]#[N:8])(=[O:3])[CH3:2].[H][H]>C(O)C.[Ni]>[C:1]([C:4]1[CH2:5][CH2:6][CH2:7][NH:8][C:9]=1[CH3:10])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 4237844-acetyl-5-oxohexanenitrileHCID 178418361HCID 178418361, compound

Product 1

HCID 18963356HCID 18963356, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 4,4-diacetylbutyronitrile (15.3 g, 0.1 mole) in ethyl alcohol (50 ml) over Raney nickel (2 g) was hydrogenated at room temperature and three atmospheres pressure. After hydrogen uptake had ceased, the catalyst was filtered off and the filtrate concentrated under reduced pressure to give 3-acetyl-2-methyl-1,4,5,6-tetrahydropyridine.

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-dc2e65e0e9d64610b45585b2d59cc5f1
Source dataset
uspto-grants-1991_03
Patent number
US05000946

Reaction notes

Loading…