Acetyl chloride → HCID 11131690, compound

HRID 359343Notes

Reaction equation

HRID 359343 reaction equation
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]1[CH3:12])[CH3:2].[C:13](Cl)(=O)[CH3:14]>O>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:4]([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[N:3]([CH2:1][CH3:2])[C:13]=2[CH3:14])=[CH2:12])=[C:4]1[CH3:12])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 1704321H-Indole, 1-ethyl-2-methyl-

Product 1

HCID 11131690HCID 11131690, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1-ethyl-2-methylindole (15.9 g, 0.1 mole) and acetyl chloride (9.4 g, 0.12 mole) was stirred at room temperature for 20 hours. Then, water (100 ml) was added to the reaction mixture and the resulting grains were filtered and dried. The dried product was recrystallized from toluene/methanol. Yield: 13.0 g (77.0%). M.P.: 183°-185° C. IR (KBr) spectrum was identical to that of the product in Example 1.

Workup

  1. filtrationthe resulting grains were filtered
  2. customdried
  3. customThe dried product was recrystallized from toluene/methanol

Sources & evidence

ORD record
ord-01ef8620131b4460824605b07143d404
Source dataset
uspto-grants-1991_03
Patent number
US05001105

Reaction notes

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