HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 5-(Propan-2-yl)morpholin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | L-Valinol | HCID 640993 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(Propan-2-yl)morpholin-3-one | HCID 20063803 | — |
Reaction Steps
Treatment of valinol in basic ethanol with chloroacetyl chloride using the procedure of Surry, et. al., J. Am. Chem. Soc. (1955) 77, 633, gives 5-(2-propyl)-3-morpholinone. Deprotonation of the latter with NaH in DMF solution and reaction with methyl iodide gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05001113 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-e914668a7438475a80d2827f7442899a |
| Source note | uspto-grants-1991_03 |