反应详情

To a stirred mixture of 80 parts of 1-butanol, 0.4 parts of sodium hydroxide and 0.94 parts of phenol were added 2.2 parts of 3-chloro-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine at 60° C. The whole was stirred and refluxed over weekend. The reaction mixture was evaporated. The residue was crystallized from 2,2'-oxybispropane. The product was filtered off and dried, yielding 2 parts (64%) of 3-butoxy-6-[4(3-methylphenyl)-1-piperazinyl]pyridazine; mp. 105.2° C. (compound 257).

1. temperaturerefluxed over weekend
2. customThe reaction mixture was evaporated
3. customThe residue was crystallized from 2,2'-oxybispropane
4. filtrationThe product was filtered off
5. customdried