反应详情

To a mixture of 6.5 g of commercially available 1-(2-aminoethyl)-2-imidazolidone and 50 ml benzene was added 5.5 ml of phenyl isocyanate. The strongly exothermic reaction was moderated by cooling to 25°. The mixture was stirred at 25° for 4 hr. It was cooled in ice and the mixture was filtered. The solid product was crystallized from 250 ml of acetone to give 6.8 g of white 1-[2-(2-oxo-1-imidazolidinyl)ethyl]-3-phenylurea, mp 162°-164°.

1. customThe strongly exothermic reaction
2. temperatureby cooling to 25°
3. temperatureIt was cooled in ice
4. filtrationthe mixture was filtered
5. customThe solid product was crystallized from 250 ml of acetone