HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | (S)-(-)-N-Boc-prolinol | HCID 643448 | — |
| Reactant | HCID 178418287 | HCID 178418287 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate | HCID 2734674 | 68.7% |
Reaction Steps
Following the procedure of Example 2, 16.0 g of pyridinium chlorochromate, 10.0 g of (S)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester, 36.0 g of crushed 4Å molecular sieves and 4.5 ml of glacial acetic acid in 250 ml of methylene chloride gives 6.8 g of the product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05001142 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-2fe1c2b80720484490532f36fc52894e |
| Source note | uspto-grants-1991_03 |