Potassium Carbonate → HCID 20065036, compound

Participants

Reaction Steps

2-Chloronicotinic acid and 4,5-dichloro-2-methoxyphenol are reacted in the presence of potassium carbonate in dimethylformamide to give 2-(4,5-dichloro-2-methoxyphenoxy)nicotinic acid, which is reacted with thionyl chloride in dichloroethane to be converted into the acid chloride. This acid chloride is reacted with ethoxymagnesium.diethyl malonate in a mixed solvent of chlorobenzene and ethanol, followed by treatment with conc. hydrochloric acid and acetic acid to obtain the acetyl compound. This acetyl compound is reacted with benzaldehyde in the presence of a small amount of sodium hydroxide in ethanol to give 2-(4,5-dichloro-2-methoxyphenoxy)-3-cinnamoylpyridine. This compound is treated with aluminium chloride to give 2-(4,5-dichloro-2-hydroxyphenoxy)-3-cinnamoylpyridine.

Provenance & Evidence