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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 359478Generated: October 25, 2026

Sodium hydride → 3-Cyano-2-(6-dimethylaminohexyloxy)pyridine

https://huagongshe.com/reaction/359478

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant6-Dimethylaminohexan-1-olHCID 74623—
Reactant2-ChloronicotinonitrileHCID 81079—
ReactantSodiumHCID 5360545—
SolventTolueneHCID 1140—
Product3-Cyano-2-(6-dimethylaminohexyloxy)pyridineHCID 15135639—

Reaction Steps

6-Dimethylaminohexanol is converted into its sodium salt with sodium hydride in toluene, followed by reaction of the sodium salt with 2-chloro-3-cyanopyridine to give 3-cyano-2-(6-dimethylaminohexyloxy)pyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05001137
Source datasetuspto-grants-1991_03
ORD IDord-92f31da8126842d3985a154613783827
Source noteuspto-grants-1991_03