Water → HCID 15135645, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1.3 g of 60% sodium hydride in 20 ml of toluene is added 5.1 g of 2-oxopyrrolidine, followed by addition of 7.4 g of 2-chloro-3-(4-methoxybenzoyl)pyridine. The mixture is stirred at 50° C. for 1 hour. After the reaction mixture is poured into water, the toluene layer is washed with water and the solvent thereof is distilled off. The residue is recrystallized from a mixed solvent of isopropyl ether and ethyl acetate to give 3-(4-methoxybenzoyl)-2-(2-oxopyrrolidin-1-yl)pyridine, m.p. 76°-77° C.

Provenance & Evidence