Azadirachtin → 108168-76-9

Participants

Reaction Steps

Azadirachtin (30 mg, 0.042 mmol) and 0.5 ml of ethanol was stirred with 20 mg of 5% palladium on alumina at 20° C. under hydrogen (10 atm) for 3 hours. The reaction mixture was then filtered and rotary evaporated in vacuo. The crude product was purified by silica gel preparative HPLC (solvent=2-propanol:n-hexane, 17:83, v/v), followed by ODS preparative HPLC (solvent=methanol:water, 1:1, v/v) to give 2',3',22,23-tetrahydroazadirachtin (18 mg).

Provenance & Evidence