HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-[[3-(Hexadecyloxy)-2-methoxypropoxy]methyl]benzenemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-O-hexadecyl-2-O-methylglycerol | HCID 1380 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1,3-Benzenedimethanol | HCID 69374 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[[3-(Hexadecyloxy)-2-methoxypropoxy]methyl]benzenemethanol | HCID 19939554 | — |
Reaction Steps
To a suspension of 2.8 g of sodium hydride in 25 ml of dimethylformamide was added at 0° C. over 30 minutes a solution of 1,3-benzenedimethanol in 75 ml of dimethylformamide. After 30 minutes a solution of 3-(hexadecyloxy)-2methoxy-1-propanol, 4-methyl benzene sulfonate in 25 ml of dimethylformamide was added over 30 minutes. After stirring 18 hours the mixture was poured into water and extracted with ethylacetate. The solution was dried and the product was purified by chromatography giving 4.7 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411983 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-b803c018fdff491c8fff6b3c2b716dd8 |
| Source note | uspto-grants-1995_05 |