1-Benzylpiperazine → HCID 15292054, compound

Participants

Reaction Steps

To a solution of 1 63 g (5 mmole) of 4-bromo-2-hydroxy-2-phenyl-1-piperidino-3-butanone in 35 mL of ether is added 1.76 g (5 mmole) of 4-benzylpiperazine. The solution is stirred at room temperature for 18 hours and then washed twice with brine dried over anhydrous sodium sulfate and the solvent removed under reduced pressure. Purification by flash column chromatography gives 2-hydroxy-2-phenyl-1-piperidino-4-(4-benzyl-1-piperazinyl)-3-butanone. This was converted into its hydrochloride salt in the usual manner.

Provenance & Evidence