HCID 10452275, compound → HCID 10090968, compound

HRID 359562Notes

Reaction equation

HRID 359562 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]([CH2:14][OH:15])[C:12]([CH3:17])([CH3:16])[CH2:11][CH:10]([O:18][Si:19]([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20])[CH:9]=2)=[CH:4][C:3]=1[CH3:26]>CS(C)=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]([CH:14]=[O:15])[C:12]([CH3:17])([CH3:16])[CH2:11][CH:10]([O:18][Si:19]([C:22]([CH3:23])([CH3:24])[CH3:25])([CH3:20])[CH3:21])[CH:9]=2)=[CH:4][C:3]=1[CH3:26]

Participants

3

Reactant 1

HCID 10452275HCID 10452275, compound

Product 1

HCID 10090968HCID 10090968, compoundYield 49.9%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In a manner similiar to Scheme I, 16 (43.5 g, 0.115 mol) was treated with sulfur trioxide pyridine complex (56.0 g, 0.345 mol) in anhydrous DMSO and workup provided 21.6 g of brown oil which was taken forward without additional purification.

Sources & evidence

ORD record
ord-b39eff21deb24938aa6f0e66964751f6
Source dataset
uspto-grants-1991_03
Patent number
US05001144

Reaction notes

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