HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → HCID 10029608, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | HCID 10069715 | HCID 10069715 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 10029608 | HCID 10029608 | — |
Reaction Steps
In a manner similiar to Scheme I, 19 (13.45 g, 33.4 mmol) was treated with LDA-derived dianion of methyl acetoacetate (40.1 mmol) in THF and, after workup and purification by HPLC. using 4:1 hexanes:EtOAc as eluent provided 7.8 g of an orange color oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05001144 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-bc3167d5b03749e6a9fbf0715e4dbe61 |
| Source note | uspto-grants-1991_03 |