Sodium Hydroxide → HCID 14671517, compound

Participants

Reaction Steps

Octylphenyl N,N-diisobutylcarbamoyl phosphine oxide was prepared by reacting octylphenyl phosphine oxide with N,N-diisobutylchloroacetamide under basic conditions using phase transfer conditions. The octyl phenyl phosphine oxide (357.5 grams) was added over a two hour period to a solution of 308.5 grams of N,N-diisobutylchloroacetamide in 600 ml. of CH2Cl2 and 300 ml. of a 50% NaOH solution containing 3.5 grams of "Adogen 464." A stirring rate of 250 rpm and a temperature of 35° C. to 40° C. was used. The reaction was continued until all the octyl phenyl phosphine oxide was consumed as determined by a GC analysis of the mixture. The reaction mixture was diluted with water. The organic layer was separated, dried over anhydrous MgSO4 and stripped of solvent to give a crude product.

Provenance & Evidence