N,N-Diethylethylenediamine → 4-([2-(N,N-diethylamino)ethyl]aminocarbonyl)benzoic acid

HRID 35960Notes

Reaction equation

HRID 35960 reaction equation
C(O[C:9]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=1)=[O:10])C1C=CC=CC=1.[CH2:20]([N:22]([CH2:26][CH3:27])[CH2:23][CH2:24][NH2:25])[CH3:21]>>[CH2:20]([N:22]([CH2:23][CH2:24][NH:25][C:9]([C:11]1[CH:12]=[CH:13][C:14]([C:15]([OH:17])=[O:16])=[CH:18][CH:19]=1)=[O:10])[CH2:26][CH3:27])[CH3:21]

Participants

3

Reactant 2

HCID 60993N,N-DiethylethylenediamineHCID 105871574-((Benzyloxy)carbonyl)benzoic acid

Product 1

HCID 115218714-([2-(N,N-diethylamino)ethyl]aminocarbonyl)benzoic acid

Procedure

4-([2-(N,N-diethylamino)ethyl]aminocarbonyl)benzoic acid was prepared from 4-benzyloxycarbonylbenzoic acid by reaction with N,N-diethylethylene diamine to yield the mono amide derivative which was hydrogenolysed to give the acid (CI-MS: m/z 265 [M+b]+).

Sources & evidence

ORD record
ord-65c05d3a7c4048fa95c6e4a60246683b
Source dataset
uspto-grants-1995_05
Patent number
US05411984

Reaction notes

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