HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 178429178, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,5-Bis(chloroacetoxy)-2-methylbenzoyl chloride | HCID 14124720 | — |
| Reactant | benzhydryl (6R,7R)-7-[[(2Z)-2-(5-amino-2-trityl-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-[(7-methyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | HCID 140355309 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178429178 | HCID 178429178 | 60% |
Reaction Steps
To an ice-cooled solution of the product obtained in Step 4 (0.6 g) in dry dichloromethane (15 ml) was added potassium carbonate (0.1 g) at once, followed by dropwise addition of a solution of 4,5-bis(chloroacetoxy)-2-methylbenzoyl chloride (0.25 g) in dry dichloromethane (10 ml). The mixture was stirred under ice cooling for one hour and then at room temperature for an additional two hours. After filtering off the insoluble matters, the filtrate was washed with water and with brine, and dried over anhydrous sodium sulfate. The dried solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography, giving 0.47 g of the objective compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05001121 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-8255951c1de1422e8aecb2fdf86a864b |
| Source note | uspto-grants-1991_03 |