참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 1-Amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid | HCID 271593 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | Isopropyl 1-amino-4-bromoanthraquinone-2-carboxylate | HCID 19800488 | — |
반응 단계
The starting 1-amino-4-bromoanthraquinone-2-carboxylic acid is reacted with 1.5 to 3 molar equivalents of a chlorinating agent such as thionyl chloride at a temperature of 80 to 100° C. for a period of about 1 to 3 hours in the presence of 0.01 to 5 molar equivalents (based on the raw material) of pyridine in 3 to 7-fold weight an amount of an inert solvent such as orthodichlorobenzene, chlorobenzene, toluene or xylene so as to be converted into an acid chloride. After the excess chlorinating agent has been removed therefrom under reduced pressure, 1.5 to 5 molar equivalents of isopropyl alcohol is added thereto and esterification is then performed at 60 to 80° C. for 1 to 3 hours. Afterward, the product is allowed to stand, thereby obtaining crystals of isopropyl 1-amino-4-bromoanthraquinone-2-carboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05002925 |
|---|
| 출처 데이터셋 | uspto-grants-1991_03 |
|---|
| ORD ID | ord-5766164820754fc3be50fa4245b1695e |
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| 출처 메모 | uspto-grants-1991_03 |
|---|
