2-(Methylamino)ethanol → 2-(Methyl(2-hydroxyethyl)amino)benzothiazole

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chlorobenzothiazole (8.5 g) and 2-methylaminoethanol (20 ml) was heated at 120° C. under pressure in a sealed, glass lined, stainless steel reaction vessel for 18 hours. After cooling, the oil was added to water (100 ml), extracted with dichloromethane (2×100 ml), the organic extracts were dried (MgSO4), filtered and evaporated to dryness Chromatography of the residual oil on silica-gel in 21/2% methanol in dichloromethane gave the title compound which was used in Preparation 1 without further purification. 1H NMR δ (CDCl3) 3.15 (3H, s); 3.4-4.0 (4H, m); 4.7 (1H, broad s, exchanges with D2O; 6.8-7.6 (4H, complex).

Provenance & Evidence