Hydrochloric Acid → HCID 19765108, compound

Participants

Reaction Steps

To a solution of ethyl 2-[[3,5-bis(1,1-dimethylethyl)-4hydroxyphenyl]thio]propanoate (1.16 g, 3.4 mmole) from Example 5 in absolute ethanol (20ml) was added lithium hydroxide hydrate (0.2g, 4.8 mmole). Water was added until the solution became cloudy and the mixture was then stirred for 20 hours Additional lithium hydroxide hydrate (0.75 g, 17.9 mmole) was added and the mixture was stirred for another two hours. The mixture was poured into 0.5 N hydrochloric acid (75 ml) and extracted with diethyl ether (100 ml in two portions). The ether extract was dried over magnesium sulfate, filtered, and concentrated in vacuo to a solid. Recrystallization from hexane gave the title compound, m.p. 110°-113°.

Provenance & Evidence