Methyl 5-bromofuran-2-carboxylate → HCID 19996108, compound

HRID 359744Notes

Reaction equation

HRID 359744 reaction equation
Br[C:2]1[O:6][C:5]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][CH:3]=1.[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][C:19]#[CH:20]>>[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][C:19]#[C:20][C:2]1[O:6][C:5]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 599633Methyl 5-bromofuran-2-carboxylateHCID 19996123HCID 19996123, compound

Product 1

HCID 19996108HCID 19996108, compoundYield 40.6%

Procedure

Methyl 5-bromo-2-furancarboxylate (1.49 g) was treated with 3-[(5-bromopentyl)oxy]-1-propyne (1.49 g) according to the method of Intermediate 9 to give the title compound as a yellow oil (0.97 g), t.l.c. (cyclohexane-diethyl ether 10:1) Rf 0.18.

Sources & evidence

ORD record
ord-915b875edf8a4ebdbe58f97d1962f406
Source dataset
uspto-grants-1991_03
Patent number
US05002966

Reaction notes

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