Water → HCID 20063871, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 1(b), 1.85 g of ethyl 3-(2-amino-5-phenoxyphenyl)thio-3-(3-fluoro-4-methoxyphenyl)-2-hydroxypropionate [prepared as described in step (a) above ] was hydrolyzed in ethanol using an aqueous solution prepared from 334 mg of 85% caustic potash. After water and ethyl acetate had been added to the reaction mixture, its pH was adjusted to a value of 3 by the addition of an aqueous solution of potassium hydrogen sulfate. The mixture was then extracted with ethyl acetate. The extract was washed with an aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and then concentrated by evaporation under reduced pressure. The residue Was triturated in diethyl ether, filtered and dried to give 922 mg of the title compound.

Provenance & Evidence