Potassium Carbonate → HCID 57158223, compound

Participants

Reaction Steps

400 mg of (±)-cis-2-(3-fluoro-4-methoxyphenyl)-2,3- dihydro-3-hydroxy-8-phenoxy-1,5-benzothiazepin-4(5H)-one [prepared as described in step (c) above] were alkylated with 210 mg of dimethylaminoethyl hydrochloride hydrochloride, 202 mg of potassium carbonate and small amounts of 4-dimethylaminopyridine and 18-crown-6 in 30 ml of acetone in the same manner as described in Example 1(d). The product was then extracted and purified as described in Example 1(d), to give 230 mg of the title compound as a gum.

Provenance & Evidence