Acetic Anhydride → HCID 9849695, compound

HRID 359766Notes

Reaction equation

HRID 359766 reaction equation
[CH3:1][N:2]([CH3:34])[CH2:3][CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][C:14]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:15][C:10]=2[S:9][C@@H:8]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([F:31])[CH:24]=2)[C@@H:7]([OH:32])[C:6]1=[O:33].[C:35](OC(=O)C)(=[O:37])[CH3:36]>N1C=CC=CC=1>[C:35]([O:32][C@H:7]1[C:6](=[O:33])[N:5]([CH2:4][CH2:3][N:2]([CH3:1])[CH3:34])[C:11]2[CH:12]=[CH:13][C:14]([O:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:15][C:10]=2[S:9][C@H:8]1[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([F:31])[CH:24]=1)(=[O:37])[CH3:36]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 57158223HCID 57158223, compound

Product 1

HCID 9849695HCID 9849695, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

455 mg of (±)-cis-5-(2-dimethylaminoethyl)-2-(3- fluoro-4-methoxyphenyl)-2,3-dihydro-3-hydroxy-8-phenoxy-1,5-benzothiazepin-4(5H)-one (prepared as described in Example 3) were acetylated in the same manner as described in Example 2 in 2 ml of pyridine using 1 ml of acetic anhydride and the product was isolated and purified also as described in Example 2, to give 480 mg of the title compound as a gum.

Workup

  1. customthe product was isolated
  2. custompurified also

Sources & evidence

ORD record
ord-2410b21150674385b36949f4f262eab5
Source dataset
uspto-grants-1991_03
Patent number
US05002942

Reaction notes

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