Potassium Hydroxide → HCID 20063844, compound

HRID 359767Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[S:15][CH:16]([C:24]1[CH:29]=[CH:28][C:27]2[O:30][CH2:31][O:32][C:26]=2[CH:25]=1)[CH:17]([OH:23])[C:18]([O:20]CC)=[O:19].[OH-].[K+]>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[S:15][CH:16]([C:24]1[CH:29]=[CH:28][C:27]2[O:30][CH2:31][O:32][C:26]=2[CH:25]=1)[CH:17]([OH:23])[C:18]([OH:20])=[O:19]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 20063855HCID 20063855, compound

Product 1

HCID 20063844HCID 20063844, compoundYield 55%

Procedure

Following a procedure similar to that described in Example 1(b), 15.2 g of ethyl 3-(2-amino-5-phenoxy- phenyl)thio-2-hydroxy-3-(3,4-methylenedioxyphenyl)propionate [prepared as described in step (a) above] were hydrolyzed with caustic potash to give 7.84 g of the title compound as a powder, melting at 158-159° C. This product was used in the next step without further purification.

Sources & evidence

ORD record: ord-b6e2e6d8f85b4ecaa9da6286c88986c7
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05002942

Reaction notes

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