N,N-Dimethylaminoethyl chloride hydrochloride → HCID 57247912, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 11(d), 865 mg of (2S, 3S)-2-(3-fluoro-4-methoxy- phenyl)-8-(4-fluorophenoxy)-2,3-dihydro-3-hydroxy-1,5-benzothiazepin-4(5H)-one [prepared as described in step (c) above] were alkylated with 2-dimethylaminoethyl chloride hydrochloride in 50 ml of methyl ethyl ketone to afford about 900 mg of the title compound as a syrup. The compound was used in the following reaction without further purification.

Provenance & Evidence