HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → 3-(4-Carboxybutyl)-5-methylisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 5-Methyl-3-isoxazolepropionic acid | HCID 133360 | — |
| Reactant | 3-(3-Bromopropyl)-5-methyl-1,2-oxazole | HCID 13316975 | — |
| Product | 3-(4-Carboxybutyl)-5-methylisoxazole | HCID 13316976 | 56% |
Reaction Steps
3-(4-Carboxybutyl)-5-methylisoxazole was prepared from 5-methyl-3-(3-bromopropyl)isoxazole and diethyl malonate according to the procedure of part (c) above, and was obtained in 56% yield as a colorless solid, m.p. 58°-60° C. when recrystallized from carbon tetrachloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05002960 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-626d6bb3d1374ea8868e82ac2b233138 |
| Source note | uspto-grants-1991_03 |