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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 359857Generated: October 26, 2026

3,5-Dimethylisoxazole → Isoxazole, 5-(5-chloro-3-pentynyl)-3-methyl-

https://huagongshe.com/reaction/359857

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DimethylisoxazoleHCID 9312—
Reactant1,4-Dichloro-2-butyneHCID 13182—
ReactantButyllithiumHCID 178418339—
ProductIsoxazole, 5-(5-chloro-3-pentynyl)-3-methyl-HCID 9989916—

Reaction Steps

The intermediate 5-(5-chloro-3-pentynyl)-3-methylisoxazole was prepared from 3,5-dimethylisoxazole and 1,4-dichloro-2-butyne in the presence of n-butyllithium.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05002960
Source datasetuspto-grants-1991_03
ORD IDord-a50de44dda884f228fb171683ca94384
Source noteuspto-grants-1991_03