Gamma-Aminobutyric Acid → HCID 45074851, compound

HRID 359868Notes

Reaction equation

HRID 359868 reaction equation
[CH2:1]([CH2:6][NH2:7])[CH2:2][C:3]([OH:5])=[O:4].[CH:8]1(O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.S(Cl)([Cl:17])=O>>[ClH:17].[CH:8]1([O:4][C:3](=[O:5])[CH2:2][CH2:1][CH2:6][NH2:7])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 119Gamma-Aminobutyric AcidHCID 7966CyclohexanolHCID 24386Thionyl Chloride

Product 1

HCID 45074851HCID 45074851, compound

Procedure

GABA (8 g, 77.6 mmol) was suspended in 100 mL (0.96 mol) of cyclohexanol. Thionyl chloride (40 mL) was added dropwise to the mixture at 0° C. The mixture was then refluxed for 4 hours, cooled and crystallized from ethyl ether. The white crystals obtained in this manner were filtered and dried. NMR analysis confirmed the identity of the product.

Workup

  1. temperatureThe mixture was then refluxed for 4 hours
  2. temperaturecooled
  3. customcrystallized from ethyl ether
  4. customThe white crystals obtained in this manner
  5. filtrationwere filtered
  6. customdried

Sources & evidence

ORD record
ord-53e2a42cea2746c88610e8d563e1a140
Source dataset
uspto-grants-1991_03
Patent number
US05002935

Reaction notes

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