HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nicotinic Acid → 1-{N-[3-(10,11-Dihydro-5H-dibenz[b,f]-azepin-5-yl)]propyl-N-methylaminocarbonyloxy]ethyl 3-pyridinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nicotinic Acid | HCID 938 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Chloroethyl N-[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)]propyl-N-methylcarbamate | HCID 15679987 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-{N-[3-(10,11-Dihydro-5H-dibenz[b,f]-azepin-5-yl)]propyl-N-methylaminocarbonyloxy]ethyl 3-pyridinecarboxylate | HCID 15679989 | 38.9% |
Reaction Steps
Following the general procedure of Example 52, but using 1.05 g (0.0028 mol) of the product of Example 51, 0.45 g (0.036 mol) of nicotinic acid and 0.36 g of triethylamine in 10 mL dimethylformamide and carrying out the reaction at 25°-30° C. for 48 hours, gave 0.5 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05002935 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-49cc95f606e54fdc981d5a54a3d01f9b |
| Source note | uspto-grants-1991_03 |