反应详情

To 5.3 g (0.03 mol) of nicotinoyl chloride in 30 mL of dry pyridine at 0° C. were added 2.0 g (0.0073 mol) of β-estradiol. The reaction mixture was refluxed for 1 hour, then was poured over 100 mL of ice water, and the resulting precipitate was collected by filtration. The precipitate was dried in vacuo over P2O5, affording 3.18 g (90%) of the title compound melting at 148°-150° C.

1. temperatureThe reaction mixture was refluxed for 1 hour
2. filtrationthe resulting precipitate was collected by filtration
3. dry with materialThe precipitate was dried in vacuo over P2O5