Methyl iodide → HCID 86744498, compound

HRID 359878Notes

Reaction equation

HRID 359878 reaction equation
[C:1]1([C:7]([O:9][C:10]2[CH:27]=[CH:26][C:25]3[C@@H:24]4[C@H:15]([C@H:16]5[C@@:20]([CH2:22][CH2:23]4)([CH3:21])[C@@H:19]([O:28][C:29]([C:31]4[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=4)=[O:30])[CH2:18][CH2:17]5)[CH2:14][CH2:13][C:12]=3[CH:11]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:37][I:38]>CC(C)=O>[I-:38].[CH3:37][N+:33]1[CH:34]=[CH:35][CH:36]=[C:31]([C:29]([O:28][C@H:19]2[CH2:18][CH2:17][C@H:16]3[C@H:15]4[C@H:24]([CH2:23][CH2:22][C@:20]23[CH3:21])[C:25]2[CH:26]=[CH:27][C:10]([O:9][C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[O:8])=[CH:11][C:12]=2[CH2:13][CH2:14]4)=[O:30])[CH:32]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 67675188HCID 67675188, compound

Product 1

HCID 86744498HCID 86744498, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The product of Example 73 (1.5 9, 3.1 mmol) was suspended in 2.5 mL of acetone. Then, 2 mL of methyl iodide were added and the reaction mixture was refluxed overnight. The yellow solid (1.8 g, 93%) was collected by filtration and dried in vacuo. UV, NMR and elemental analyses confirmed that the product had the assigned structure: ##STR108##

Workup

  1. temperaturethe reaction mixture was refluxed overnight
  2. filtrationThe yellow solid (1.8 g, 93%) was collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-b3e2f1fd9fcc422eb8b7e10ff4dc2f31
Source dataset
uspto-grants-1991_03
Patent number
US05002935

Reaction notes

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