反应详情

A neat mixture of 2-aminoethanol (6.1 g, 0.10 mol) and ethyl nicotinate (15.1 g, 0.10 mol) was refluxed overnight. As the mixture was cooled to room temperature, the product precipitated as a crystalline solid. It was filtered, washed with ether and then recrystallized from 2-propanol/ether. The final product was collected by vacuum filtration and washed with ether. The dried, white compound weighed 10.7 g, resulting in a 64.5% yield; mp 88.5°-89.5° C. (lit. value 92° C.).

1. temperaturewas refluxed overnight
2. customthe product precipitated as a crystalline solid
3. filtrationIt was filtered
4. washwashed with ether
5. customrecrystallized from 2-propanol/ether
6. filtrationThe final product was collected by vacuum filtration
7. washwashed with ether
8. customresulting in a 64.5% yield
9. custommp 88.5°-89.5° C. (lit. value 92° C.)