反应详情

352 g (4.4 moles) of 50% strength sodium hydroxide solution were added dropwise, in the course of 30 minutes, to a boiling mixture of 392 g (4 moles) of 2-isopropylacrolein, 1,280 g (40 moles) of methanol and 720 g (8.8 moles) of 30% strength formaldehyde and the refluxed mixture was then stirred for a further 60 minutes. It was then evaporated down, methyl isobutyl ketone was added and the residual water was separated off by azeotropic distillation. Precipitated sodium formate was filtered off and the filtrate was distilled. 504 g (78% yield) of 2-methoxymethyl-2-isopropyl-1,3-propanediol of boiling point 96°-100° C./1 mbar were obtained.

1. customIt was then evaporated down
2. additionmethyl isobutyl ketone was added
3. customthe residual water was separated off by azeotropic distillation
4. filtrationPrecipitated sodium formate was filtered off
5. distillationthe filtrate was distilled