HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylacetamide → Quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | 4,5-Difluorophthalic Anhydride | HCID 639745 | — |
| Reactant | 4,5-Difluorophthalic Acid | HCID 643382 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Quinoline | HCID 7047 | — |
| Product | 3,4-Difluorobenzoic acid | HCID 99166 | — |
Reaction Steps
Surprisingly, we have found that 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid may be selectively decarboxylated in N-methyl-pyrrolidone, dimethyl acetamide or quinoline to yield 3,4-difluorobenzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05003103 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-e5f44cf93a7c49a0ba418940a37b3b97 |
| Source note | uspto-grants-1991_03 |