HCID 86748663, compound → Loracarbef

HRID 35997Notes

Reaction equation

HRID 35997 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([C@@H:7]([NH2:24])[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[C@@H:12]2[CH2:13][CH2:14][C:15]([Cl:23])=[C:16]3[C:20]([OH:22])=[O:21])=[O:9])=[CH:5][CH:6]=1.C([O-])C>O>[CH:1]1[CH:2]=[CH:3][C:4]([C@@H:7]([NH2:24])[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[C@@H:12]2[CH2:13][CH2:14][C:15]([Cl:23])=[C:16]3[C:20]([OH:22])=[O:21])=[O:9])=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 86748663HCID 86748663, compound

Product 1

HCID 5284585Loracarbef

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Loracarbef ethanolate (5.0 g, 86.2%, potency as loracarbef), from above was suspended in 70 ml of H2O, and the slurry was heated to 50° C. The slurry became very thick which indicated conversion to the monohydrate. The slurry was stirred at 50° C. for 1 hour, filtered, washed with H2O and dried under vacuum at 40° C. The actual yield of loracarbef monohydrate was 3.06 g, 102.8% potency as loracarbef monohydrate, the theoretical yield was 4.53 g, and the percent yield was 69.3%.

Workup

  1. filtrationfiltered
  2. washwashed with H2O
  3. customdried under vacuum at 40° C

Sources & evidence

ORD record
ord-1321aab279fc4b5da55cd6271e0c0bc2
Source dataset
uspto-grants-1995_05
Patent number
US05412094

Reaction notes

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