Hydrochloric Acid → N-heptyl-4-butylbenzenemethanamine

HRID 359996Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 359996
[CH2:1]([NH:8][C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Cl>O1CCCC1>[CH2:1]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 13733121Benzamide, 4-butyl-N-heptyl-

Produkt 1

HCID 15137718N-heptyl-4-butylbenzenemethanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 38.0 g of N-heptyl-4-n-butylbenzamide and 280 ml of borane-tetrahydrofuran complex in 120 ml of anhydrous tetrahydrofuran was refluxed for 18 hours, allowed to cool, and treated with 6N hydrochloric acid. The organic solvent was evaporated and the residue was partitioned between ether and aqueous sodium hydroxide solution. The ether layer was separated, dried, and evaporated. The residue was distilled to yield N-heptyl-4-n-butylbenzenemethanamine as a colorless liquid, bp 115°C. at 80μ.

Aufarbeitung

  1. temperatureto cool
  2. customThe organic solvent was evaporated
  3. customthe residue was partitioned between ether and aqueous sodium hydroxide solution
  4. customThe ether layer was separated
  5. customdried
  6. customevaporated
  7. distillationThe residue was distilled

Quellen und Nachweise

ORD-Eintrag
ord-931275d5ae124c35b72b6a8335895b6e
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US05003106

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