Hexane → HCID 13733074, compound

HRID 360003Notes

Reaction equation

HRID 360003 reaction equation
C1(O[C:8](=[O:19])[NH:9][C:10]2[C:15]([CH3:16])=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=2[CH3:18])C=CC=CC=1.[CH3:20][C:21]([CH3:38])([CH3:37])[CH2:22][CH2:23][NH:24][CH2:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[CH:28][CH:27]=1.CCCCCC>C1(C)C=CC=CC=1>[CH3:20][C:21]([CH3:38])([CH3:37])[CH2:22][CH2:23][N:24]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[CH:28][CH:27]=1)[C:8]([NH:9][C:10]1[C:11]([CH3:18])=[CH:12][C:13]([Cl:17])=[CH:14][C:15]=1[CH3:16])=[O:19]

Participants

5

Reactant 3

HCID 8058HexaneHCID 13733128HCID 13733128, compoundHCID 13733131HCID 13733131, compound

Product 1

HCID 13733074HCID 13733074, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 825 mg of phenyl-N-(4-chloro-2,6-dimethylphenyl)carbamate and 782 mg of N-(3,3-dimethylbutyl)-4-(2,2-dimethylpropyl)benzenemethanamine in 40 ml of toluene was heated to reflux for 1 hour, cooled, and the solution was washed with 1N sodium hydroxide, brine, dried, and evaporated to dryness to yield a solid. The solid was recystallized from hexane to yield 1-[3,3-dimethylbutyl]-1-[[4-(2,2-dimethylpropyl)phenyl]methyl]-3-[4-chloro-2,6-dimethylphenyl]urea as a white solid, mp 148°-150° C.

Workup

  1. temperatureto reflux for 1 hour
  2. temperaturecooled
  3. washthe solution was washed with 1N sodium hydroxide, brine
  4. customdried
  5. customevaporated to dryness
  6. customto yield a solid

Sources & evidence

ORD record
ord-792cae9519e542a79e2ee2ba85b69e44
Source dataset
uspto-grants-1991_03
Patent number
US05003106

Reaction notes

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