反应详情

温度

25 °C

A solution of (4R-cis)-1,1-dimethylethyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, 1.36 % (4.97 mol), and (±)-4-fluoro-a-[2-methyl-1-oxopropyl ]-γ-oxo-N,β--diphenylbenzenebutaneamide mixture of [R-(R',R')], [R-(R',S')], [S-(R',R')]and [S-R',S')]isomers, 1.60 g (3.83 mol), in 50 mL of heptane:toluene (9:1) is heated at reflux for 24 hours. The solution is cooled slightly and 15 mL of 2-propanol added. The mixture is allowed to cool to 25° C. and filtered to give 1.86 g of (R-cis)-1,1dimethylethyl 6-[2[2-(4-fluorophenyl)-5-(1-methyl-ethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate as a yellow solid with acceptable PNMR & C-NMR spectra.

1. temperatureat reflux for 24 hours
2. temperatureThe solution is cooled slightly
3. filtrationfiltered